ceesdekker No Further a Mystery

ceesdekker No Further a Mystery

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Working with solitary-molecule optical and AFM imaging and power-spectroscopy techniques, we request to unravel the mechanistic areas of the construction and dynamics of chromosomes. Our study pursuits involve:

Human Rad51 filaments on double- and solitary-stranded DNA: correlating common and irregular forms with recombination operate.

Dynamics of initiation, termination and reinitiation of DNA translocation through the motor protein EcoR124I

Non-equilibrium folding of unique DNA molecules recaptured up to a thousand situations in a solid point out nanopore

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Experimental period diagram of negatively supercoiled DNA measured by magnetic tweezers and fluorescence,

We use nanofabricated microfluidic structures to pattern spatial boundaries for bacteria and biomimetic vesicles with reconstituted protein networks and this evaluate the elemental job of spatial confinement within the molecular and mobile stage. Our initiatives incorporate the next:

Atomic pressure microscopy shows that vaccinia topoisomerase IB generates filaments on DNA in the cooperative manner

‘You shouldn't just contemplate the issues of tomorrow, but will also evaluate the thoughts of the working day just after tomorrow’

1). The present–voltage curves showed important modulations with gate voltage, even at room temperature, which was in keeping with band bending inside a ~0.six eV bandgap semiconducting nanotube. These data also cees dekker confirmed which the conductance could possibly be modulated by 6 orders of magnitude by altering the gate voltage. The final results of this operate — a room-temperature transistor made out of only one carbon nanotube molecule — had been posted in Nature in May well 1998.

An integrated microfluidic platform for quantifying drug permeation throughout biomimetic vesicle membranes

1999, to start with measurement in the wavefunction of one molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive evidence for the new Luttinger description of interacting electrons in nanotubes

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‘I am driven by surprise and issues. On a cloth amount I find answers in physics, but I expertise my deepest pleasure with God. That religion also drives my science And exactly how I cope with folks.